Keratinocyte-Secreted Heat Shock Protein-90alpha: Leading Wound Reepithelialization and Closure
نویسندگان
چکیده
منابع مشابه
Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing.
Hypoxia is a microenvironmental stress in wounded skin, where it supports wound healing by promoting cell motility. The mechanism of the hypoxia action remained speculative. Here, we provide evidence that hypoxia promotes human dermal fibroblast (HDF) migration by inducing secretion of heat shock protein-90alpha (hsp90alpha) into the extracellular environment through hypoxia-inducible factor-1a...
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There is large literature describing in vitro experiments on heat shock protein (hsp)B1 but understanding of its function in vivo is limited to studies in mice overexpressing human hspB1 protein. Experiments in cells have shown that hspB1 has chaperone activity, a cytoprotective role, regulates inflammatory gene expression, and drives cell proliferation. To investigate the function of the prote...
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ژورنال
عنوان ژورنال: Advances in Wound Care
سال: 2016
ISSN: 2162-1918,2162-1934
DOI: 10.1089/wound.2014.0620